Abdominal Irradiation Ameliorates Obesity in ob/ob Mice

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Abdominal Irradiation Ameliorates Obesity in ob/ob Mice

Leptin-deficient ob/ob mice are a murine model for obesity, insulin resistance, and diabetes. Here we report that non-lethal abdominal irradiation (a single fraction of 850 cGy) to ob/ob mice retarded rapid gain of body weight, leading to amelioration of obesity without marked changes in food intake. This effect was observed only in ob/ob mice and not in lean controls. Reduction of body weight ...

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ژورنال

عنوان ژورنال: Journal of Clinical Biochemistry and Nutrition

سال: 2007

ISSN: 1880-5086,0912-0009

DOI: 10.3164/jcbn.40.123